Cameco - 40-F annual report 2022

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM

40-F

☐

REGISTRATION STATEMENT

PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE

ACT OF 1934

☒

ANNUAL REPORT PURSUANT TO SECTION 13(a) or

15(d) OF THE SECURITIES EXCHANGE ACT OF

1934

For the fiscal year ended

December 31, 2022

Commission file number

1-14228

CAMECO CORPORATION

(Exact name of Registrant as specified in its charter)

Canada

(Province or other jurisdiction of incorporation or organization)

1090

(Primary Standard Industrial Classification Code Number)

98-0113090

(I.R.S. Employer Identification)

2121 – 11

Street West

Saskatoon

Saskatchewan

Canada

S7M 1J3

, Telephone:

(

306

)

956-6200

(Address and telephone number of Registrant’s principal executive offices)

Cristina Giffin, Power Resources, Inc., Smith Ranch-Highland Operation

762 Ross Road

Douglas

Wyoming

, USA,

82633

Telephone: (

307

)

358-6541

(Name, address, (including zip code) and telephone number (including area code) of agent for service in the United States)

Securities registered pursuant to Section 12(b) of the Act:

Title of Class:

Common Shares

par value

Trading Symbol(s):

CCJ

Name of Exchange where Securities are listed:

New York Stock Exchange

Securities registered or to be registered pursuant to Section 12(g) of

the Act:

None

Securities for which there is a reporting obligation pursuant

to Section 15(d) of the Act:

None

Information filed with this Form:

☒

Annual Information Form

☒

Audited annual financial statements

Number of outstanding shares of each of the issuer’s classes

capital or common stock as of the close of the period covered by

the annual report:

432,518,470

Common Shares outstanding as of December 31, 2022

Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of

the Exchange

Act during

the preceding

12 months

(or for

such shorter

period that

the Registrant

was required

file such reports), and (2) has been subject to such filing requirements

for the past 90 days.

☒

Yes

☐

Indicate by check

mark whether the

registrant has submitted

electronically,

every Interactive Data

File required to

be submitted pursuant to Rule 405 of

Regulation S-T (§232.405 of this chapter) during the

preceding 12 months (or

for such shorter period that the Registrant was required

to submit and post such files).

☒

Yes

☐

Indicate

check

mark

whether

the

registrant

emerging

growth

company

defined

Rule

12b-2

the

Exchange Act.

Emerging growth company

☐

If an emerging

growth company

that prepares

its financial

statements in

accordance with

U.S. GAAP,

indicate by

check mark

if the

registrant has

elected not

to use

the extended

transition period

for complying

with any

new or

revised financial accounting standards†

provided pursuant to Section 13(a) of the Exchange

Act.

☐

Indicate by check mark

whether the registrant has filed a

report on and attestation to

its management’s assessment

of the effectiveness

of its internal

control over financial

reporting under Section

404(b) of the

Sarbanes-Oxley Act

(15 U.S.C. 7262(b)) by the registered public accounting

firm that prepared or issued its audit report.

☑

securities

are

registered

pursuant

Section

12(b)

the

Exchange

Act,

indicate

check

mark

whether

the

financial

statements

the

registrant

included

the

filing

reflect

the

correction

error

previously

issued

financial statements.

☐

Indicate by check

mark whether any

of those error

corrections are restatements

that required a

recovery analysis

of incentive-based compensation received by any of the registrant’s executive officers

during the relevant recovery

period pursuant to §240.10D-1(b).

☐

FORWARD-LOOKING

STATEMENTS

Certain statements

in this

Annual Report on

Form 40-F

and the documents

filed as exhibits

hereto, and including

certain information

about Cameco’s

business outlook,

objectives, strategies,

plans, strategic

priorities and

results

of operations, as well as

other statements which are

not current statements or

historical facts, constitute “forward-

looking information

”

within the

meaning of

applicable

Canadian securities

laws and

“forward-looking

statements”

within

the

meaning

the

Private

Securities

Litigation

Reform

Act

1995.

Forward-looking

information

and

statements

involve

risks,

uncertainties

and

other

factors

that

could

cause

actual

results

differ

materially

from

those

expressed

implied

them.

Sentences

and

phrases

containing

words

such

“anticipate”,

“believe”,

“estimate”,

“expect”,

“forecast”,

“goal”,

“intend”,

“outlook”,

“plan”,

“potential”,

“predict”,

“project”,

“proposed”,

“scheduled”,

“strategy”,

“target”

and

“will”,

and

the

negative

any

these

words

variations

them

comparable terminology that does not relate strictly

to current or historical facts, are all

indicative of forward-looking

information or statements.

The forward-looking information and statements included

in this Annual Report on Form 40-F (including the

exhibits hereto) represent our views as of the date of

such documents and should not be relied upon as

representing our views as of any subsequent date. While we

anticipate that subsequent events and developments

may cause our views to change, we specifically disclaim

any intention or obligation to update forward-looking

information and statements, whether as a result of new information,

future events or otherwise, except to the

extent required by applicable securities laws. Forward-looking

information and statements contained in this

Annual Report on Form 40-F about prospective results

of operations, financial position or cash flows that are

based upon assumptions about future economic conditions

and courses of action are presented for the purpose

of assisting our security holders in understanding management’s

current views regarding those future outcomes,

and may not be appropriate for other purposes.

See Cameco’s Annual Information Form for the year

ended December 31, 2022, attached as Exhibit

99.1 to this

Annual Report on Form 40-F,

under the heading “Caution about forward-looking information”

and Cameco’s

management’s discussion and analysis for the year

ended December 31, 2022, attached as Exhibit 99.3 to

this

Annual Report on Form 40-F (the “Cameco 2022 MD&

A”), under the heading “Caution about forward-looking

information”, for a discussion of forward-looking statements.

Certifications and Disclosure Regarding Controls and

Procedures

(a)

Certifications regarding controls and procedures

See Exhibits 99.6 and 99.7.

(b)

Evaluation of

disclosure controls

and procedures

. As

of December

31, 2022

an evaluation

of the

effectiveness of Cameco Corporation’s “disclosure controls and procedures” (as such term is defined in

Rules 13a-15(e) and 15d-15(e) of the United States Securities Exchange Act of 1934, as amended (the

“Exchange Act”)) was carried ou

by Cameco Corporation’s

Chief

Executive Officer (“CEO”)

and Chief

Financial Officer (“CFO”). Based on

that evaluation, the CEO and CFO have concluded

that as of such

date Cameco

Corporation’s

disclosure controls

and procedures

are effective

to provide

a reasonable

level of

assurance that

information

required

to be

disclosed

by Cameco

Corporation

in reports

that it

files or

submits under

the Exchange

Act is

recorded, processed,

summarized and

reported within

the

time periods specified in United States Securities

and Exchange Commission (the “Commission”) rules

and forms.

It should be noted that

while the CEO and

CFO believe that Cameco

Corporation’s disclosure controls

and procedures provide a reasonable

level of assurance that

they are effective, they

do not expect the

disclosure controls

and procedures or

internal control

over financial reporting

to be

capable of preventing

all

errors

and

fraud.

control

system,

matter

how

well

conceived

operated,

can

provide

only

reasonable, not absolute, assurance that the objectives of the control

system are met.

(c)

Management’s

annual

report

internal

control

over

financial

reporting

Management

the

Company,

including

the

CEO

and

CFO,

responsible

for

establishing

and

maintaining

adequate

“internal control over financial reporting”, as that term is

defined in Rules 13a-15(f) and 15d-15(f) under

the Exchange Act, for Cameco Corporation. Management conducted an evaluation of the effectiveness

of internal control

over financial reporting

based on criteria

established in Internal

Control – Integrated

Framework (2013) issued by

the Committee of

Sponsoring Organizations of the

Treadway Commission.

Based

that

evaluation,

management

concluded

that

Cameco

Corporation’s

internal

control

over

financial reporting was effective as of December 31,

2022.

(d)

Attestation

report

the

registered

public

accounting

firm

The

effectiveness

Cameco

Corporation’s internal

control over financial

reporting as

of December 31,

2022 was

audited by KPMG

LLP,

an independent

registered public

accounting firm,

as stated

in its

report, which

accompanies the

Cameco

2022

Consolidated

Audited

Financial

Statements

that

filed

Exhibit 99.2

this

Annual

Report on Form 40-

(e)

Changes

internal

control

over

financial

reporting

During

the

fiscal

year

ended

December 31,

2022, there was no significant change in

Cameco Corporation’s internal control

over financial reporting

that has

materially affected,

or is

reasonably likely

to materially

affect,

Cameco Corporation’s

internal

control over financial reporting.

Audit & Finance

Committee Financial

Expert

Cameco Corporation’s

board of

directors has determined

that at

least one member of its audit and finance committee (the “audit committee”) is an audit committee financial expert.

The audit committee financial expert

is Daniel Camus. Mr.

Camus has been determined by Cameco

Corporation’s

board

directors

independent

director

such

term

defined

under

the

Canadian

Securities

Administrators’

National Instr

ument 52-110

(Audit Committees)

(“NI 52-110”)

the Commission’s

audit committee

independence

requirements,

and

the

rules

the

New

York

Stock

Exchange

(the

“NYSE”)

relating

the

independence of audit committee members.

Information concerning the relevant

experience of Mr.

Camus is included in his biographical

information contained

in Cameco Corporation’s Annual Information Form

that is filed as Exhibit 99.1 to this Annual Report on Form

40-F.

The Commission

has indicated

that the

designation

of a

person as

an audit

committee financial

expert does

not

make such person

an “expert”

for any purpose,

impose any

duties, obligations

or liability on

such person

that are

greater

than

those

imposed

members

the

audit

committee

and

board

directors

who

not

carry

this

designation, or affect the

duties, obligations or liability

of any other member of

the audit committee or

the board of

directors.

Code of

Ethics

Cameco Corporation’s code

of conduct and

ethics (the

“Code”) is applicable

to all

directors, officers

and

employees

Cameco

Corporation,

including

the

Company’s

principal

executive

officer,

principal

financial

officer and principal

accounting officer.

The Code, as

well as

Cameco Corporation’s corporate governance

practices

and mandates

of the

board of

directors

and

its committees,

and position

descriptions

for the

CEO and

the non-

executive chair, can be found on Cameco Corporation’s website at www.cameco.com under “About – Governance”

and are

also available

in print

to any

shareholder

upon request.

Since the

adoption of

the Code,

there have

not

been

any

waivers,

including

implied

waivers,

from

any

provision

the

Code.

2022,

Cameco

Corporation

amended

its

previously

filed

Code

and

made

non-substantive

changes,

including

the

addition

information

psychological safety;

diversity,

equity and

inclusion; human

rights; and

compliance with

sanctions.

Except as

set

forth in this

Annual Report on

Form 40-F, the information on the

Company’s website is not

part of this

Annual Report

on Form 40-

The

Code

was

furnished

the

Commission

January

13,

2023

Exhibit

report

Form

6-K

and

incorporated by reference herein as Exhibit 99.17.

Principal

Accountant

Fees

and

Services

Our

independent

registered

public

accounting

firm

KPMG LLP

Saskatoon, Saskatchewan, Canada

, Auditor Firm ID:

. See Exhibit 99.4.

Off-Balance

Sheet Arrangements

In the

normal course

of operations,

Cameco Corporation

enters into

certain

transactions that

are not

required to

be recorded

on its

balance sheet.

These activities include

the issuing

of financial

assurances

and long-term

product purchase

contracts. These

activities are

disclosed in

the following

sections

Exhibit 99.3

– 2022

Management’s

Discussion

and Analysis

and

the notes

to the

financial

statements

in Exhibit

99.2 – 2022 Consolidated Audited Financial Statements:

(a)

Financial assurances

. In the 2022 Management’s Discussion and Analysis, see the disclosure at “Off-

balance sheet

arrangements”

(page 54).

In the

2022 Consolidated

Audited Financial

Statements, see

the disclosure at notes 16 and 26 of the financial statements.

(b)

Long-term product purchase contracts

. In the 2022 Management’s Discussion and

Analysis, see the

disclosure at “Off-balance sheet arrangements” (page

54).

(c)

Other arrangements

. In the 2022

Management’s Discussion

and Analysis, see

the disclosure at

“Off-

balance sheet

arrangements” (page

54). In

the 2022

Consolidated Audited

Financial Statements,

see

the disclosure at notes 14 and 15

of the financial statements.

Tabular

Disclosure

Contractual

Obligations

the

2022

Management’s

Discussion

and

Analysis,

see

the

disclosures at “Financing Activities” (pages 53 and

54) and “Off-balance sheet arrangements”

(page 54).

Identification

the

Audit

Committee.

Cameco

Corporation

has

separately-designated

standing

audit

committee established

in accordance

with Section

3(a)(58)(A)

of the

Exchange Act.

Cameco Corporation’s

audit

committee

comprised

of:

Daniel

Camus

(chair),

Ian

Bruce,

Catherine

Gignac,

Jim

Gowans

and

Leontine

van

Leeuwen-Atkins.

Audited Annual Financial Statements

The report of the independent registered public accounting firm

relating to

Cameco Corporation’s Consolidated Audited

Financial Statements as of December

31, 2022 and 2021 is included

in Exhibit 99.2 – 2022 Consolidated Audited Financial

Statements.

Mine Safety Disclosure

Neither Cameco Corporation

nor any of

its subsidiaries

is the “operator”

of any “coal

other mine”, as those terms

are defined in section 3 of

the Federal Mine Safety and Health

Act of 1977 (30 U.S.C.

802),

that

subject

the

provisions

such

Act

(30

U.S.C.

801

seq.).

Therefore,

the

provisions

Section

1503(a) of the Dodd-Frank Wall

Street Reform and Consumer

Protection Act and Item 16 of

General Instruction B

to Form

40-F requiring

disclosure concerning

mine safety

violations and

other regulatory

matters do

not apply

Cameco Corporation or any of its subsidiaries or U.S.

mines.

Disclosure Regarding Foreign Jurisdictions That Prevent

Inspections.

Not Applicable

Disclosure Pursuant to the Requirements of the New

York Stock Exchange

(a)

Corporate

governance

practices

Disclosure

the

significant

ways

which

Cameco

Corporation’s

corporate governance

practices differ

from those

required for

U.S. companies

under the

New York

Stock

Exchange (“NYSE”) listing standards can be found

on Cameco Corporation’s website at www.cameco.com

under “About – Governance.”

(b)

Presiding director at meetings of

non-management directors

. Cameco Corporation schedules regular

director sessions

in which

Cameco Corporation’s

“non-management

directors” (as

that term

is defined

the rules

of the

NYSE) meet

without management

participation. Mr.

Ian Bruce,

as non-executive

chair of

Cameco Corporation, serves

as the presiding director

(the “Presiding Director”)

at such sessions. Each

Cameco Corporation’s non-management directors is “independent” as such term is used in the rules of the

NYSE.

Cameco

Corporation’s

criteria

for

director

independence

are

available

Cameco

Corporation’s

website at www.cameco.com

under “About – Governance.”

(c)

Communication with non-management directors

. Shareholders may send communications

to Cameco

Corporation’s Presiding Director

or non-management directors

by mailing (by regular

mail or other means

of delivery)

to the

corporate head

office at

2121 –

Street West,

Saskatoon, Saskatchewan,

Canada,

S7M 1J3, in a sealed envelope

marked “Private and Strictly

Confidential – Attention: Chair of

the Board of

Directors of Cameco Corporation”. Any such envelope will be delivered unopened to

the Presiding Director

for appropriate

action. The

status of

all outstanding

concerns addressed

to the

Presiding Director

will be

reported to the board of directors as appropriate.

(d)

Corporate governance guidelines

. According to Section 303A.09 of the

NYSE Listed Company Manual,

a listed

company must adopt

and disclose

a set

of corporate governance

guidelines with

respect to

specified

topics. Such

guidelines and

the charters

of the

listed company’s

most important

committees of

the board

directors

are

required

posted

the

listed

company’s

website

and

available

any

shareholder upon request. Cameco

Corporation operates under corporate

governance guidelines that are

consistent

with

the

requirements

Section

303A.09

the

NYSE

Listed

Company

Manual.

Cameco

Corporation’s

corporate

governance guidelines

and the

charters of

its most

important committees

of the

board

directors

can

found

Cameco

Corporation’s

website

www.cameco.com

under

“About

–

Governance” and are available in print to any shareholder who

requests them.

(e)

Independent directors

. The names

of Cameco Corporation’s

non-management directors

are: Ian Bruce,

Daniel

Camus,

Donald

Deranger,

Catherine

Gignac,

Jim Gowans,

Kathryn

Jackson,

Don Kayne

and

Leontine van

Leeuwen-Atkins.

Each of

the non-management

directors

is “independent”,

as such

term is

used in the rules of the NYSE.

EXHIBIT INDEX

Exhibit No.

Description

99.1

2022 Annual Information Form

99.2

2022 Consolidated Audited Financial Statements

99.3

2022 Management’s Discussion and Analysis

99.4

Principal Accountant Fees and Services

99.5

Consent of Independent Registered Public Accounting Firm

99.6

Certification of Chief Executive Officer pursuant to Rule 13a-14(a) or 15d 14(a) of the U.S.

Securities Exchange Act of 1934, as amended

99.7

Certification of Chief Financial Officer pursuant to Rule 13a-14(a) or 15d 14(a) of the U.S.

Securities Exchange Act of 1934, as amended

99.8

Certification of Chief Executive Officer pursuant to Section 906 of the Sarbanes-Oxley Act of

2002

99.9

Certification of Chief Executive Officer pursuant to Section 906 of the Sarbanes-Oxley Act of

2002

99.10

Consent of Alain D. Renaud, P. Geo.

99.11

Consent of Biman Bharadwaj, P. Eng.

99.12

Consent of Scott Bishop, P. Eng.

99.13

Consent of Lloyd Rowson, P. Eng.

99.14

Consent of Gregory M. Murdock, P. Eng.

99.15

Consent of Sergey Ivanov, P. Geo.

99.16

Consent of Daley McIntyre, P. Eng.

99.17

Code of Conduct and Ethics (as amended and restated as of July 2022) (incorporated by

reference to Cameco Corporation’s Form 6-K, furnished to the Commission on January 13,

2023)

101

Interactive Data File (formatted as Inline XBRL)

104

Cover Page Interactive Data File (formatted as Inline

XBRL and contained in Exhibit 101)

UNDERTAKING AND

CONSENT TO SERVICE OF PROCESS

Undertaking

Registrant undertakes to

make available, in

person or by

telephone, representatives

to respond to

inquiries made

by the

Commission staff,

and to

furnish promptly,

when requested

to do

so by

the Commission

staff,

information

relating to: the

securities registered

pursuant to

Form 40-F; the

securities in

relation to

which the obligation

to file

an Annual Report on Form 40-F arises; or transactions

in said securities.

Consent to Service of Process

Registrant has previously

filed a

Form F-X in

connection with the

class of

securities in relation

to which

the obligation

to file this Annual Report on Form 40-F arises.

Any

change

the

name

address

the

agent

for

service

process

Registrant

shall

communicated

promptly

the

Commission

amendment

the

Form

F-X

referencing

the

file

number

the

relevant

registration statement.

SIGNATURES

Pursuant to the requirements of the Exchange Act, Registrant certifies that it meets all of the requirements for filing

on Form 40-F and

has duly caused this

Annual Report to be

signed on its behalf

by the undersigned, thereto

duly

authorized.

DATED this 29

day of March,

2023.

CAMECO CORPORATION

By:

/s/ Grant Isaac

Name: Grant Isaac

Title:

Executive Vice-President and

Chief Financial Officer

Cameco - 40-F annual report 2022

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